CXCR3-CXCL9: It’s All in the Tumor

CXCL9: evidence and contradictions for its role in tumor progression

Chemokines are a group of low molecular weight peptides. Their major function is the recruitment of leukocytes to inflammation sites, but they also play a key role in tumor growth, angiogenesis, and metastasis. In the last few years, accumulated experimental evidence supports that monokine induced by interferon (IFN)-gamma (CXCL9), a member of CXC chemokine family and known to attract CXCR3- (C...

Increased expression of Cxcr3 and its ligands, Cxcl9, and Cxcl10, during the development of alopecia areata in the mouse

Caroline G. McPhee1, F. Jason Duncan2, Kathleen A. Silva1, Lloyd E. King Jr.3, Harm HogenEsch4, Derry C. Roopenian1, Helen B. Everts2, and John P. Sundberg1,3 1The Jackson Laboratory, Bar Harbor, ME 2Department of Nutrition, The Ohio State University, Columbus, OH 3Division of Dermatology, Vanderbilt University, Nashville, TN 4Department of Comparative Pathobiology, Purdue University, West Lafa...

Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells

Cathepsin B (CTSB) is a lysosomal cysteine protease that has been linked to the progression of breast cancer, for example by activation of other proteases and tumor-promoting cytokines, thereby supporting tumor invasion and metastasis. Previously, it was shown that CTSB cleaves and inactivates C-X-C motif chemokine receptor 3 (CXCR3) chemokines. As CXCR3 ligands have been demonstrated to induce...

Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria.

Cerebral malaria is a significant cause of global mortality, causing an estimated two million deaths per year, mainly in children. The pathogenesis of this disease remains incompletely understood. Chemokines have been implicated in the development of cerebral malaria, and the IFN-inducible CXCR3 chemokine ligand IP-10 (CXCL10) was recently found to be the only serum biomarker that predicted cer...

CXCR3 Ligand CXCL9 Allergic Airway Hyperreactivity by the Regulation of Cockroach Antigen-Induced